In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin
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چکیده
منابع مشابه
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.
N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]- phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) has been selected from a chemical program aimed at identifying an optimized inhibitor of multidrug resistance (MDR). The potency of GF120918 is assessed by dose-dependent sensitization of CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2010
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6605716